Biologic Chemistry

Immunochemistry

Immunochemistry involves the study of the immune system and the detection of antibodies, antigens, and immune complexes. In immunochemistry experiments, the quality of water is critical for various applications such as antibody labeling, immunoassays, and immunoprecipitation. High-purity water is essential to prevent interference with immune reactions and ensure the success of immunochemistry experiments.

What Is The Impact Of Water In Immunochemistry?

Water quality significantly influences the success of immunochemistry experiments. Contaminated water can introduce impurities into samples, affect antibody-antigen interactions, and compromise the accuracy of immunochemical analyses. High-purity water is necessary to maintain the integrity of immune reactions, ensuring reliable results in immunochemistry experiments.

What Types Of Contaminants In Water Can Affect Immunochemistry?

Water impurities that can impact immunochemistry experiments include:

Bacteria & Microorganisms

Impact:

Bacterial contamination can adversely affect immunochemistry assays.

Effect:

Unintended microorganisms may interfere with the specificity of immunochemical reactions, leading to variations in assay results and compromising the reliability of immunochemistry studies. This can affect the accuracy of antibody-antigen interactions.

Endotoxins

Impact:

Endotoxins can affect the performance of immunochemistry techniques.

Effect:

In immunochemistry experiments, endotoxins may trigger unwanted immune responses, affecting the binding kinetics of antibodies and antigens. This can lead to inaccuracies in immunochemical analyses and compromise the reliability of results.

Organic Compound

Impact:

Small organic compounds in water can introduce unwanted signals in immunochemistry assays.

Impact:

Organic impurities, such as humic acids and pesticides, may affect the specificity of antibody binding. Removal of these organic compounds from immunochemistry reagents is crucial to ensure accurate and reliable immunochemical results.

Ionic Contaminants

Impact:

Ionic contaminants can interfere with immunochemical reactions.

Impact:

Elevated levels of ions may affect the stability of antibody-antigen complexes, leading to variations in immunochemistry results. Maintaining low levels of ionic contaminants is essential for the reproducibility and accuracy of immunochemical analyses.

Water Measurement Requirements for Immunochemistry

Immunochemistry involves complex interactions between antibodies and antigens, making water quality a critical factor in obtaining reliable results. The choice of water type depends on the sensitivity of the immunochemical assays performed. Apyrogenic, Type I ultrapure water is often recommended to meet stringent purity standards.

Water Quality Standards According to Industry Guidelines:

Resistivity (MΩ.cm)*

>18

TOC (ppb)

<10

Filter (μm)

<0.2

Bacteria (CFU/ml)

Endotoxins (EU/ml)

<0.002

Nucleases

Not detected

Resistivity (MΩ.cm)*

TOC (ppb)

Filter (μm)

Bacteria (CFU/ml)

Endotoxins (EU/ml)

Nucleases

>18

<10

<0.2

<0.002

Not detected

Adhering to these water quality standards is crucial for the success and accuracy of immunochemistry experiments. Type I water is recommended for critical applications, while Type II water may be suitable for routine experiments.

NOTES:

If removal of finer particulates (< 0.05 micron) is required, consider upgrading to CLS-5400 series systems.
Applications requiring Endotoxin filtration should purchase a CLF-5000-02E Endotoxin removal final filter.

System

Label

System Depth (in)

System Height (in)

System Width (in)

Dry Weight (lbs)

Inlet Connection

System Voltage

TOC Monitoring

0.05μ Ultrafiltration

Ultraviolet Oxidation

Effluent Purity

Effluent Microorganisms

Effluent Sodium

Effluent Chlorides

Effluent TOC

System Maximum
Output (lpm)

Volumetric Presets

Mounting

Laboratory Applications

CAtegory

CLS-3300

Get a quote

Download Spec Sheet

CLR 3300 High Purity Lab Water System with 0.05 Micron Ultrafiltration

25.25

⅜" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 10 CFU / ml

< 1ppb

< 15 ppb

Countertop, Wall Mount

Cell Culture, Electrophoresis, Immunochemistry, Life Sciences, Microbiology

Biologic Chemistry

CLS-5300-R-1

Get a quote

Download Spec Sheet

CLïR 5300 Ultrapure Lab Water System with Ultrafiltration (Remote 120v)

14.4

21.6

14.7

⅜" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 15 ppb

Wall Mount, Remote Dispense

Cell Culture, Electrophoresis, Immunochemistry, Life Sciences, Microbiology

Biologic Chemistry

CLS-5300-R-2

Get a quote

Download Spec Sheet

CLïR 5300 Ultrapure Lab Water System with Ultrafiltration (Remote 220v)

14.4

21.6

14.7

⅜" O.D. Tubing

220V/50Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 15 ppb

Wall Mount, Remote Dispense

Cell Culture, Electrophoresis, Immunochemistry, Life Sciences, Microbiology

Biologic Chemistry

CLS-5300-S-1

Get a quote

Download Spec Sheet

CLïR 5300 Ultrapure Lab Water System with Ultrafiltration (Standard 120v)

14.4

21.6

14.7

⅜" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 15 ppb

Countertop

Cell Culture, Electrophoresis, Immunochemistry, Life Sciences, Microbiology

Biologic Chemistry

CLS-3300

Get a quote

Download Spec Sheet

CLR 3300 High Purity Lab Water System with 0.05 Micron Ultrafiltration

25.25

⅜" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 10 CFU / ml

< 1ppb

< 15 ppb

Countertop, Wall Mount

Cell Culture, Electrophoresis, Immunochemistry, Life Sciences, Microbiology

Biologic Chemistry

CLS-5300-R-1

Get a quote

Download Spec Sheet

CLïR 5300 Ultrapure Lab Water System with Ultrafiltration (Remote 120v)

14.4

21.6

14.7

⅜" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 15 ppb

Wall Mount, Remote Dispense

Cell Culture, Electrophoresis, Immunochemistry, Life Sciences, Microbiology

Biologic Chemistry

CLS-5300-R-2

Get a quote

Download Spec Sheet

CLïR 5300 Ultrapure Lab Water System with Ultrafiltration (Remote 220v)

14.4

21.6

14.7

⅜" O.D. Tubing

220V/50Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 15 ppb

Wall Mount, Remote Dispense

Cell Culture, Electrophoresis, Immunochemistry, Life Sciences, Microbiology

Biologic Chemistry

CLS-5300-S-1

Get a quote

Download Spec Sheet

CLïR 5300 Ultrapure Lab Water System with Ultrafiltration (Standard 120v)

14.4

21.6

14.7

⅜" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 15 ppb

Countertop

Cell Culture, Electrophoresis, Immunochemistry, Life Sciences, Microbiology

Biologic Chemistry

The difference is CLïR.

Get a quote

Applications

Biologic Chemistry

Immunochemistry

What Is The Impact Of Water In Immunochemistry?

Bacteria & Microorganisms

Endotoxins

Organic Compound

Ionic Contaminants

Water Measurement Requirements for Immunochemistry

Resistivity (MΩ.cm)*

TOC (ppb)

Filter (μm)

Bacteria (CFU/ml)

Endotoxins (EU/ml)

Nucleases

System

Label

System Depth (in)

System Height (in)

System Width (in)

Dry Weight (lbs)

Inlet Connection

System Voltage

TOC Monitoring

0.05μ Ultrafiltration

Ultraviolet Oxydation

Effluent Purity

Effluent Microorganisms

Effluent Sodium

Effluent Chloride

Effluent TOC

System MaximumOutput (lpm)

Volumetric Presets

Mounting

Laboratory Applications

Laboratory Applications

CAtegory

System

Label

System Depth (in)

System Height (in)

System Width (in)

Dry Weight (lbs)

Inlet Connection

System Voltage

TOC Monitoring

0.05μ Ultrafiltration

Ultraviolet Oxydation

Effluent Purity

Effluent Microorganisms

Effluent Sodium

Effluent Chloride

Effluent TOC

System MaximumOutput (lpm)

Volumetric Presets

Mounting

Laboratory Applications

Laboratory Applications

CAtegory

System

Label

System Depth (in)

System Height (in)

System Width (in)

Dry Weight (lbs)

Inlet Connection

System Voltage

TOC Monitoring

0.05μ Ultrafiltration

Ultraviolet Oxydation

Effluent Purity

Effluent Microorganisms

Effluent Sodium

Effluent Chloride

Effluent TOC

System MaximumOutput (lpm)

Volumetric Presets

Mounting

Laboratory Applications

Laboratory Applications

System Maximum
Output (lpm)

System Maximum
Output (lpm)

System Maximum
Output (lpm)

System Maximum
Output (lpm)

System Maximum
Output (lpm)

System Maximum
Output (lpm)