Gas Chromatography Mass Spectrometry (GC/MS) is a powerful analytical technique used for separating and identifying compounds in complex mixtures. In GC/MS, the quality of the carrier gas and solvents, including water, is crucial for achieving accurate and reliable results. Ensuring high-purity water is essential to minimize interference and maintain the integrity of the chromatographic and mass spectrometric analyses.
What Is The Impact Of Water On GC/MS?
The quality of water directly impacts the performance of GC/MS. Impurities in water can introduce background signals, affect chromatographic peak shapes, and impact and accuracy of mass spectrometric analyses, leading to unreliable results.
What Types Of Contaminants In Water Can Affect Academia?
Water impurities that can impact GC/MS results include:
Ionic Contaminants
Impact:
Elevated levels of ions can interfere with GC/MS analyses.
Impact:
Excess ions may affect the ionization process, leading to background signals and variations in mass spectra. In electron impact ionization, for instance, interference from ions can compromise the accuracy of compound identifications.
Organic Contaminants
Impact:
The presence of organic impurities can affect the sensitivity and specificity of GC/MS analyses.
Impact:
In qualitative analyses, unintended organic compounds may contribute to additional peaks, affecting the interpretation of mass spectra and potentially compromising the reliability of compound identifications.
Particulates
Impact:
Presence of particulate matter in GC/MS samples can cause column contamination
Impact:
Particulates may lead to column degradation and affect the reproducibility of retention times. This interference can compromise the precision of GC/ MS analyses.
Water Measurement Requirements for GC/MS
Gas Chromatography Mass Spectrometry (GC/MS) is a technique used for the separation and identification of volatile compounds. The choice of water type is crucial to ensure that the solvents and reagents used in sample preparation do not introduce impurities that may interfere with the analysis. For applications demanding high sensitivity in the detection of voltatile compounds, the use of apyrogenic, Type I ultrapure water is strongly recommended.
Water Quality Standards According to Industry Guidelines:
Method
Sensitivity
Resistivity (MΩ.cm)*
TOC (ppb)
Filter (μm)
Bacteria (CFU/ml)
Endotoxins (EU/ml)
Nucleases
GC
General
>5
<50
<0.2
<10
NA
NA
GC
High
>18.0
<2
<0.2
<1
NA
NA
GC-MS
High
>18.0
<2
<0.2
<1
NA
NA
Method
GC
Sensitivity
General
Resistivity (MΩ.cm)*
>5
TOC (ppb)
<50
Filter (μm)
<0.2
Bacteria (CFU/ml)
<10
Endotoxins (EU/ml)
NA
Nucleases
NA
Method
GC
Sensitivity
High
Resistivity (MΩ.cm)*
>18.0
TOC (ppb)
<2
Filter (μm)
<0.2
Bacteria (CFU/ml)
<1
Endotoxins (EU/ml)
NA
Nucleases
NA
Method
GC-MS
Sensitivity
High
Resistivity (MΩ.cm)*
>18.0
TOC (ppb)
<2
Filter (μm)
<0.2
Bacteria (CFU/ml)
<1
Endotoxins (EU/ml)
NA
Nucleases
NA
Adhering to these water quality standards is crucial for achieving accurate and reproducible results in GC/MS analyses. Type I water is recommended for applications requiring the highest level of sensitivity, while Type Il water may be suitable for routine analyses.
NOTES:
If removal of finer particulates (< 0.05 micron) is required, consider upgrading to CLS-5400 series systems.
CLïR 3200 High Purity Lab Water System with UV Oxidation
10
25.25
21
32
⅜" O.D. Tubing
120V/60Hz
> 18 MΩ/cm
< 10 CFU / ml
< 1ppb
< 1ppb
< 5 ppb
4
Countertop, Wall Mount
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
CLïR 5200 Ultrapure Lab Water System with TOC Monitoring & UV Oxidation (Remote 120V)
14.4
21.6
14.7
42
⅜" O.D. Tubing
120V/60Hz
> 18 MΩ/cm
< 1 CFU/ml
< 1ppb
< 1ppb
< 5 ppb
2.5
Wall Mount, Remote Dispense
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
CLïR 5200 Ultrapure Lab Water System with TOC & UV Oxidation (Remote 220V)
14.4
21.6
14.7
42
⅜" O.D. Tubing
220V/50Hz
> 18 MΩ/cm
< 1 CFU/ml
< 1ppb
< 1ppb
< 5 ppb
2.5
Wall Mount, Remote Dispense
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
CLïR 5200 Ultrapure Lab Water System with TOC Monitor & UV Oxidation (Standard 120V)
14.4
21.6
14.7
42
½" O.D. Tubing
120V/60Hz
> 18 MΩ/cm
< 1 CFU/ml
< 1ppb
< 1ppb
< 5 ppb
2.5
Countertop
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
CLïR 3200 High Purity Lab Water System with UV Oxidation
10
25.25
21
32
⅜" O.D. Tubing
120V/60Hz
> 18 MΩ/cm
< 10 CFU / ml
< 1ppb
< 1ppb
< 5 ppb
4
Countertop, Wall Mount
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
CLïR 5200 Ultrapure Lab Water System with TOC Monitoring & UV Oxidation (Remote 120V)
14.4
21.6
14.7
42
⅜" O.D. Tubing
120V/60Hz
> 18 MΩ/cm
< 1 CFU/ml
< 1ppb
< 1ppb
< 5 ppb
2.5
Wall Mount, Remote Dispense
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
CLïR 5200 Ultrapure Lab Water System with TOC & UV Oxidation (Remote 220V)
14.4
21.6
14.7
42
⅜" O.D. Tubing
220V/50Hz
> 18 MΩ/cm
< 1 CFU/ml
< 1ppb
< 1ppb
< 5 ppb
2.5
Wall Mount, Remote Dispense
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
CLïR 5200 Ultrapure Lab Water System with TOC Monitor & UV Oxidation (Standard 120V)
14.4
21.6
14.7
42
½" O.D. Tubing
120V/60Hz
> 18 MΩ/cm
< 1 CFU/ml
< 1ppb
< 1ppb
< 5 ppb
2.5
Countertop
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
CLïR 3200 High Purity Lab Water System with UV Oxidation
10
25.25
21
32
⅜" O.D. Tubing
120V/60Hz
> 18 MΩ/cm
< 10 CFU / ml
< 1ppb
< 1ppb
< 5 ppb
4
Countertop, Wall Mount
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
CLïR 5200 Ultrapure Lab Water System with TOC Monitoring & UV Oxidation (Remote 120V)
14.4
21.6
14.7
42
⅜" O.D. Tubing
120V/60Hz
> 18 MΩ/cm
< 1 CFU/ml
< 1ppb
< 1ppb
< 5 ppb
2.5
Wall Mount, Remote Dispense
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
CLïR 5200 Ultrapure Lab Water System with TOC & UV Oxidation (Remote 220V)
14.4
21.6
14.7
42
⅜" O.D. Tubing
220V/50Hz
> 18 MΩ/cm
< 1 CFU/ml
< 1ppb
< 1ppb
< 5 ppb
2.5
Wall Mount, Remote Dispense
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
CLïR 5200 Ultrapure Lab Water System with TOC Monitor & UV Oxidation (Standard 120V)
14.4
21.6
14.7
42
½" O.D. Tubing
120V/60Hz
> 18 MΩ/cm
< 1 CFU/ml
< 1ppb
< 1ppb
< 5 ppb
2.5
Countertop
Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics
.png){kind=logo}
.webp)
.webp)
.webp)
.webp)
.webp)
.png){kind=logo}
.png)
.webp)
